Exploration of the relationship between the storage time of leukodepleted red blood cell and transfusion adverse reactions / 中国输血杂志

【Objective】 To explore the relationship between the storage time of leukodepleted red blood cells and transfusion adverse reactions by analyzing the occurrence of transfusion adverse reactions of patients after leukodepleted red blood cells transfusion from four hospitals. 【Methods】 By using the electronic medical record management system, the collection and transfusion dates of leukodepleted red blood cells from four hospitals in Enshi Prefecture from 2018 to 2022, as well as the information on transfusion adverse reactions, were retrieved. 【Results】 From 2018 to 2022, a total of 697 61 bags of leukodepleted red blood cells were transfused in four hospitals, resulting in 166 cases of transfusion adverse reactions, among which 93 were allergic reactions, 63 were non hemolytic febrile reactions, and 10 were others, with a total incidence rate of transfusion adverse reactions at 0.24%. The average storage time of leukodepleted red blood cells with and without transfusion adverse reactions was (20.25±6.31) and (19.88±5.50) days, respectively. With a storage time of 7 days as the threshold, the incidence of transfusion adverse reactions was the lowest for a storage time of 15~21 days. The incidence of transfusion adverse reactions of leukodepleted red blood cells in two groups (with storage days ≤21 days and >21 days) was not statistically significant(P>0.05). 【Conclusion】 Allergic reactions were the main type of transfusion adverse reaction caused by leukodepleted red blood cells, and the incidence of transfusion adverse reactions decreased and then increased with the prolongation of the storage time of leukodepleted red blood cells. There was no significant difference in the incidence of transfusion adverse reactions with leukodepleted red blood cells stored for ≤ 21 days and >21 days.

Clinical analysis of 214 cases of blood transfusion adverse reactions / 重庆医学

Objective To understand the basic situation of blood transfusion adverse reactions to provide a basis for more ra-tionally and safely using blood in clinic.Methods A total of 24 409 cases of blood transfusion in this hospital during 2012?2015 were retrospectively analyzed.The report forms of blood transfusion adverse reactions served as the criterion for conducting the sta-tistics.Results There were 214 case of transfusion adverse reaction in this hospital during these 4 years.The incidence rate was 0. 88%.Among 5 blood components,the adverse reaction occurrence by frozen plasma was maximal,followed by single donor PLT and suspension red blood cells,which by the washed red blood cells was lowest.The blood adverse reactions showed the decreasing trend with the time and increasing trend with the age group increase.The transfusion reactions had no statistical difference between sexes and among blood types(P>0.05).Conclusion Clinical medical units should fully recognize the risk of blood transfusion,set up a standardized blood usage system and strictly implement,strengthen the blood transfusion knowledge training,advocate the au-tologous blood transfusion and clinically scientific,reasonable and safe blood usage.

Reacciones transfusionales en el Hospital Docente Provincial “Comandante Faustino Pérez” de la provincia de Matanzas / Transfusion reactions at “Comandante Faustino Pèrez” Provincial University Hospital in the province of Matanzas

A partir del año 2003, en el Hospital Docente Provincial “Comandante Faustino Pérez” se inició el control y análisis de los efectos adversos de la transfusión de sangre, mediante el reporte y estudio de todas las reacciones transfusionales, para conocer su frecuencia, tipo y gravedad, así como su relación con el componente utilizado, los días de extraído y el sexo del receptor. Se reportaron los errores detectados y subsanados antes del proceder. Este estudio se realizó bajo la asesoría y control del Banco de Sangre Provincial “Minerva Duarte”, como parte de la vigilancia sobre los productos sanguíneos y la cadena transfusional, con el objetivo de disminuir los efectos adversos e incrementar la seguridad transfusional. Los datos obtenidos demuestran disminución del número de reacciones adversas, de 52 en el 2002 a 14 en el 2005. Las más frecuentes fueron la febril no hemolítica y las alérgicas; la más grave resultó la contaminación bacteriana. Los errores más frecuentes subsanados antes de la transfusión fueron por equivocación del grupo en la bolsa a transfundir. El componente que más reacciones originó fue el concentrado de hematíes y el sexo femenino fue el que más reacciones presentó. El estudio permitió la adopción de medidas correctivas y preventivas para disminuir las reacciones e incrementar la seguridad transfusional en el centro hospitalario.

From 2003 on, it was started the control and analysis of the adverse effects of blood transfusion at “Comandante Faustino Pérez” Provincial University Hospital by the report and study of all the transfusion reactions in order to know their frequency, type and severity, as well as their relation to the component used, the date of the extraction, and the sex of the recipient. The errors detected and corrected before the procedure were reported. This study was conducted under the counselling and control of “Minerva Duarte” Provincial Blood Bank as part of the vigilance of the blood products and the transfusion chain aimed at reducing the adverse effects and at increasing transfusion safety. The data obtained showed a decrease of the number of adverse reactions from 52, in 2002, to 14, in 2005. The most common reactions were the non-hemolytic febrile reactions and the allergic reactions, whereas the most serious was bacterial contamination. The most frequent amended mistakes before transfusion were those made by the group with the transfusion bag. The packed cells proved to be the component that originated the greatest amount of reactions. Females had more reactions. The study allowed to take corrective and preventive measures to lower the reactions and improve the transfusion safety in the hospital.

Reactions in 1400 consecutive blood transfusions at the UE Ramon Magsaysay Memorial Hospital

Eighty-three instances of transfusion reactions occurred in 1400 transfusions at the UE RM Memorial Hospital of blood prepared only by its own blood bank. The over-all incidence of 5.9 compares favorably with reported figures abroad of 3.5 to 5.5. Two-thirds of these reactions and 3.92 of all transfusions were febrile while almost the remaining one-third or 1.78 of all transfusions were of allergic nature. One case each of malaria, shock and pulmonary edema were among the miscellaneous reactions. Bacteriologic cultures were positive in 8 of 90 bottles cultured at random, and in only 2 of 8 was there an accompanying reaction. One had a transient febrile reaction (staphylococcus, coagulase negative) and the other had a possible but unproven bacteremia. No instance of hemolytic reaction was detected. (Summary)

Research on Preparation of Leukocyte-Poor Platelet Concentrates by Centrifugation / 中国输血杂志

The platelet concentrates prepared by twofold centrifugation in tight quadruple-bag were subjected to the third centrifugation after their disaggregation to remove white and red blood cells from them. The effect of third centrifugation speed on the efficiency of platelet concentrates was treated. The observation of 65 bags undergoing the third 450Xg centrifugation showed that the white blood cell residual was 0. 07?108/L and the platelet recovery was 52. 5% of the whole blood, with the mediant being (5. 3?1. 6) ?1010per bag.The control study of 18-bag platelet concentrates demonstrated that the third centrifugation had no impact on the quality and extrasomatic function of platelets during their storage. The pH of leukocyte-poor platelet concentrates having been stored for 3 and 5 days was significantly higher than that of common platelet concentrates, making up 7. 2?0. 1,6. 6?0. 4,7. 1?0. 2 and 6. 3?0. 6(P